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Depression is a mental health disorder marked by persistently low mood or loss of interest in activities and severe impairment of various physical activities. Scientists and experts round the world have time and again emphasized on the seriousness of the issue which until now wasn't given the critical attention it deserves and shrugged off as a temporary "state of mind". According to a latest study, scientists may have found one of the mechanism that may trigger the condition. People suffer from major depressive disorders because of alterations in the activity and connectivity of brain systems underlying reward and memory, says a new study.