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Drinking at least three cups of coffee and not smoking daily may half the risk of mortality in patients infected by both human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Patients infected by both HIV and HCV are at specific risk of end-stage liver disease and greater risk of cardiovascular diseases and cancer. According to researchers, HIV-HCV co-infected patients, drinking at least three cups of coffee each day halved the risk of all-cause mortality. In the general population, drinking three or more cups of coffee a day has been found to be associated with a 14 percent reduction in the risk of all-cause mortality.